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Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study
Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study
- Citation
- Angiogenesis (2022)
- Date
- June 20, 2022
- Link
- View Link
Abstract Aims Although coronavirus disease 2019 (COVID-19) and bacterial sepsis are distinct conditions, both are known to trigger endothelial dysfunction with corresponding microcirculatory impairment. The purpose […]- Citation
- Pediatric Critical Care Medicine ():10.1097/ PCC.0000000000003123, January 04, 2023.
- Date
- January 4, 2023
- Link
- View Link
Abstract Objectives: To assess the disruption of endothelial glycocalyx integrity in children with sepsis receiving fluid resuscitation with either balanced or unbalanced crystalloids. The primary outcome […]- Citation
- Microvasc Res. 2013 Nov;90:86-9
- Date
- August 26, 2013
- Link
- View Link
Abstract Glycocalyx degradation may contribute to microvascular dysfunction and tissue hypoperfusion during systemic inflammation and sepsis. In this observational study we evaluated the alteration of the […]- Citation
- Microvasc Res. 2018 Jul;118:44-48. doi: 10.1016/j.mvr.2018.02.004. Epub 2018 Feb 17.
- Date
- February 17, 2018
- Link
- View Link
Abstract As of now the relationship between glycocalyx degradation and microcirculatory perfusion abnormalities in non-septic critical ill patients is unclear. In addition, conjunctival sidestream dark field-imaging […]- Citation
- Crit Care. 2019 Jul 24;23(1):260.
- Date
- July 24, 2019
- Link
- View Link
Abstract Background: The endothelial glycocalyx (eGC) covers the luminal surface of the vascular endothelium and plays an important protective role in systemic inflammatory states and particularly in […]- Citation
- Anaesth Intensive Care. 2020 May;48(3):221-228.
- Date
- June 2, 2020
- Link
- View Link
Abstract Microcirculatory alterations play an important role in the early phase of sepsis. Shedding of the endothelial glycocalyx is regarded as a central pathophysiological mechanism causing […]- Citation
- Wiley Online Library, 2018 December
- Date
- December 24, 2018
- Link
- View Link
Summary The vascular endothelial surface is coated by the glycocalyx, a ubiquitous gel-like layer composed of a membrane-binding domain that contains proteoglycans, glycosaminoglycan side-chains, and plasma […]- Citation
- Critical Care, 19 March 2021
- Date
- March 19, 2021
- Link
- View Link
Abstract Background The availability of handheld, noninvasive sublingual video-microscopes allows for visualization of the microcirculation in critically ill patients. Recent studies demonstrate that reduced numbers of blood-perfused […]- Citation
- MDPI (Multidisciplinary Digital Publishing Institute) 5 August 2021
- Date
- August 5, 2021
- Link
- View Link
Abstract The glycocalyx is an endothelial surface layer that is essential for maintaining microvascular homeostasis. Impaired integrity of the endothelial glycocalyx may be directly related to […]- Citation
- Crit Care. 2014 Feb 17;18(1):R33
- Date
- February 17, 2014
- Link
- View Link
Abstract Introduction: Microvascular alterations impair tissue oxygenation during sepsis. A red blood cell (RBC) transfusion increases oxygen (O2) delivery but rarely improves tissue O2 uptake in patients […]- Citation
- PLoS One. 2015 May 1;10(5):e0122655
- Date
- May 1, 2015
- Link
- View Link
Abstract Background: Free hemoglobin (fHb) may induce vasoconstriction by scavenging nitric oxide. It may increase in older blood units due to storage lesions. This study evaluated whether […]