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GlycoCheck is being used by researchers in hospitals and universities in Africa, Asia, Australia, China, Europe, Japan, Russia, and the United States.
Examples of Diseases and Conditions Being Researched
- Type 2 Diabetes
- Stroke
- Early Cognition Impairment
- Epilepsy
- Syndrome X
- Kidney failure / Hemodialysis
- Pre-eclampsia / HELLP
- Sepsis / Septic Shock
- Pre-Eclampsia
- Atherosclerosis
- Heart failure
- Premature Atherosclerosis
- Malaria / Dengue
- Obesity
- ESRD Proteinuria
- Inflammation
If you're interested in discovering the most vital research on the endothelial glycocalyx, as well as the internationally patented GlycoCheck, browse these studies below, or search to find studies based on topic.
- Citation
- J Rheumatol. 2017 Nov;44(11):1572-1574. doi: 10.3899/jrheum.170958. Epub 2017 Nov 1. No abstract available.
- Date
- November 1, 2017
- Link
- View Link
No abstract available- Citation
- J Rheumatol. 2017 Nov;44(11):1603-1611. doi: 10.3899/jrheum.170120. Epub 2017 Sep 15.
- Date
- September 15, 2017
- Link
- View Link
Abstract Objective: The aim of our study was to determine whether an automated capture and analysis system could detect differences in structure and function of sublingual microvessels […]- Citation
- PLoS One. 2017 Aug 22;12(8):e0183281.
- Date
- August 22, 2017
- Link
- View Link
Abstract Background: Haemodialysis (HD) patients are predisposed to dysregulated fluid balance leading to extracellular water (ECW) expansion. Fluid overload has been closely linked with outcome in these […]- Citation
- Int J Cardiol. 2017 Dec 1;248:433-439. doi: 10.1016/j.ijcard.2017.05.010. Epub 2017 Jul 18.
- Date
- July 18, 2017
- Link
- View Link
Abstract Background: We aimed to evaluate the microvascular function in patients with microvascular angina (MVA) by assessing 1) the endothelial glycocalyx barrier properties using sublingual microscopy, and […]- Citation
- Atherosclerosis. 2017 May 13;262:123-130.
- Date
- May 13, 2017
- Link
- View Link
Abstract Background and aims: The effects of medically-aided smoking cessation on vascular function and oxidative stress are not fully clarified. Methods: One hundred eighty-eight current smokers were randomized […]- Citation
- Int J Cardiol. 2017 Apr 15;233:105-112.
- Date
- April 15, 2017
- Link
- View Link
Abstract Background: First-degree relatives of type-2 diabetes patients (FDR) present insulin resistance. We investigated whether FDR and dysglycaemic subjects demonstrate abnormal endothelial glycocalyx and LV deformation during […]- Citation
- BMJ Open. 2017 Jan 5;7(1)
- Date
- January 5, 2017
- Link
- View Link
Abstract Introduction: Adequate functioning of the blood-brain barrier (BBB) is important for brain homoeostasis and normal neuronal function. Disruption of the BBB has been described in several […]- Citation
- Eur Heart J Cardiovasc Imaging. 2016 Dec 1;17(suppl_2):ii136-ii143.
- Date
- December 1, 2016
- Link
- View Link
Abstract Background: Arterial stiffness is associated with increased risk for cardiovascular disease. The purpose of this study is to investigate the arterial stiffness and myocardial deformation in […]- Citation
- Eur Heart J Cardiovasc Imaging. 2016 Dec 1;17(suppl_2)
- Date
- December 1, 2016
- Link
- View Link
- Citation
- Stomatologiia (Mosk). 2016;95(4):9-12. Russian.
- Date
- July 1, 2016
- Link
- View Link
Abstract The intactness degree of glycocalyx and the thickness of endothelium layer in sublingual microvessels was determined by means of darkfield microscopy and GlycoCheck RI software […]- Citation
- Microcirculation. 2016 Jan;23(1):69-74.
- Date
- January 1, 2016
- Link
- View Link
Abstract Objectives: Endothelial glycocalyx injury causes microcirculatory perfusion disturbances in experimental studies, but the relevance in a clinical setting remains unknown. We investigated whether glycocalyx dimensions are […]- Citation
- J Thorac Cardiovasc Surg. 2015 Dec;150(6):1474-81.
- Date
- August 24, 2015
- Link
- View Link
Abstract Objective: Perturbation of the endothelial glycocalyx is discussed in the pathogenesis of complications related to cardiopulmonary bypass. We evaluated the effects of cardiopulmonary bypass on the […]- Citation
- Am J Physiol Heart Circ Physiol. 2015 Aug 15;309(4):H711-7.
- Date
- August 15, 2015
- Link
- View Link
Abstract The mechanisms that trigger initiation of arteriogenesis in response to pathogenic obstruction of arterial flow are not fully understood. Our objective is to determine whether […]- Citation
- JHypertens. 2015 Jun;33 Suppl 1
- Date
- June 1, 2015
- Link
- View Link
Abstract Objective: Abnormal microvascular structure and function have been related to hypertension. Increasing evidence links Na+ to microvascular changes. Whether a chronic dietary Na+ load or […]- Citation
- PLoS One. 2015 May 1;10(5):e0122655
- Date
- May 1, 2015
- Link
- View Link
Abstract Background: Free hemoglobin (fHb) may induce vasoconstriction by scavenging nitric oxide. It may increase in older blood units due to storage lesions. This study evaluated whether […]
Studies on Endocalyx Pro effectiveness are ongoing. For the complete list, please go to Microvascular.com/Endocalyx-Pro-Studies
The Crucial Consortium brings together 12 partners from multiple fields (clinicians, fundamental scientists, scientific SMEs, exploitation and dissemination SME, management SME, and a patient advocacy), representing 7 different countries.
The Crucial Consortium aims to address a difficult problem regarding how co-morbidities give rise both to mental disorders and non-mental disorders. In order to achieve this, they have assembled a consortium that has a balanced mix of skills on several levels.
It consists of fundamental scientists and clinicians. It consists of specialists in neuroscience (UM, Scannexus) and in cardiovascular science (UCL, UNAV, FIMA, GlycoCheck, KU Leuven, VIB).
The clinical scientists are strong leaders in the field of MRI (UCL, UM, UNAV, Scannexus), whereas the fundamental partners have strong skills in molecular biology and genetics that will allow them to develop new biomarkers and identify new pathways for pharmaceutical targeting (FIMA, KU Leuven, VIB). Beyond bridging fundamental research and clinical applications, the project also combines several state-of-the-art technical approaches to answer the research objective. This includes cell signalling, (single cell) RNA-Seq, metabolic assessments, microvesicle’s biomarker identification, GlycoCheck measurements, and advanced imaging (MRI, 2-photon and light sheet microscopy). Read more here.
The Crucial Consortium has announced that they are launching a new study titled “Evaluation of miCRovascular rarefaction in vascUlar Cognitive Impairment and heArt faiLure (CRUCIAL): Study protocol for an observational study.” The abstract can be viewed by clicking the name of the study.
Healthy Aging is a Euregional project within the Interreg Euregio Maas-Rhine program . The partners (BIOMED is the lead partner) within this consortium ( BIOMED , MUMC + , GIGA Liège , UKA , Curador , MyHealth , Imomec , GlycoCheck , Astel Medica and DNAmito) use their expertise and knowledge to the maximum to detect premature aging of the immune system and to slow down aging and related chronic conditions. This consortium wants to develop cross-border knowledge platforms within the EMR for sharing and disseminating knowledge. Most of the activities in this project have a very specific medical-scientific focus. The partners of this project aim to innovate and validate the knowledge collected in the context of these activities. The results of this project should lead to lower healthcare costs. This project is supported by the European Regional Development Fund of the European Union which, through cross-border projects, provides innovation, stimulates a healthy environment and the labor market. More information can be found here. INTERREG Program and financing partners include:
Clinical Papers
Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit – the GlycoNurse study
Kuempers 2018: good intra-observer and excellent intra-class reproducibility of PBR measurements in ICU and ER patients; increased PBR in ICU patients compared with ER patients. PBR correlates with Mean Arterial Pressure (MAP) and with CRP and SOFA scores.
Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion
Weissgerber 2019: reproducibility of PBR measurements in pre-eclampsia patients increases when taking average of 2 or 3 measurements.
Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis
Kuempers 2019: PBR in patients correlates with plasma Syndecan-1 levels and with Atomic Force Microscope measurements of glycocalyx dimension on cultured endothelial cells exposed to patients' plasma.
Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall
Gorshkov 2018: Increase of PBR is associated with ischemic heart disease.
Experimental Papers
Rapid Insulin-Mediated Increase in Microvascular Glycocalyx Accessibility in Skeletal Muscle May Contribute to Insulin-Mediated Glucose Disposal in Rats
Eskens 2013:Insulin increases PBR, and hyaluronidase treatment of the glycocalyx abolishes the insulin effect
Early impairment of skeletal muscle endothelial glycocalyx barrier properties in diet-induced obesity in mice
Eskens 2014: PBR is increased in response to a High Fat Diet (figure 2D) and PBR correlates with increased duration and level of plasma glucose (area under the curve of glucose) after Glucose Tolerance Test.
Perturbed mechanotransduction by endothelial surface glycocalyx modification greatly impairs the arteriogenic process
Potter 2015: Inhibition of endothelial hyaluronan production increases PBR, which is associated with diminished glycocalyx dimension as measured with the Dextran 150kDa exclusion zone (figure 1).
Advanced age results in a diminished endothelial glycocalyx
Machin 2018: PBR increase in old mice is associated with decreased glycocalyx dimension, and increased PBR is associated with decreased glycocalyx dimension.