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GlycoCheck is being used by researchers in hospitals and universities in Africa, Asia, Australia, China, Europe, Japan, Russia, and the United States.
Examples of Diseases and Conditions Being Researched
- Type 2 Diabetes
- Stroke
- Early Cognition Impairment
- Epilepsy
- Syndrome X
- Kidney failure / Hemodialysis
- Pre-eclampsia / HELLP
- Sepsis / Septic Shock
- Pre-Eclampsia
- Atherosclerosis
- Heart failure
- Premature Atherosclerosis
- Malaria / Dengue
- Obesity
- ESRD Proteinuria
- Inflammation
If you're interested in discovering the most vital research on the endothelial glycocalyx, as well as the internationally patented GlycoCheck, browse these studies below, or search to find studies based on topic.
- Citation
- Clin Hemorheol Microcirc. 2018 Nov 29. doi: 10.3233/CH-180428.
- Date
- November 29, 2018
- Link
- View Link
Abstract Background: Damage of the endothelial glycocalyx (EG) has been described during surgery, but the effect of different anesthesia techniques remains unknown. Perfused boundary region (PBR) evaluated […]- Citation
- J Mol Cell Cardiol. 2019 Feb;127:74-82. doi: 10.1016/j.yjmcc.2018.11.014. Epub 2018 Nov 29.
- Date
- November 29, 2018
- Link
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Abstract Age-related vascular dysfunction in large elastic and resistance arteries is associated with reductions in microvascular perfusion and elevations in blood pressure. Recent evidence indicates that […]- Citation
- Clin Hemorheol Microcirc. 2018 Nov 2. doi: 10.3233/CH-189907. [Epub ahead of print]
- Date
- November 2, 2018
- Link
- View Link
Abstract Background and objective: The endothelial glycocalyx (EG) is fragile and sensitive to damage such as exposure to hypernatremia. Our aim was to describe the influence of […]- Citation
- Biomed Res Int. 2018 Nov 1;2018:8925345. doi: 10.1155/2018/8925345. eCollection 2018.
- Date
- November 1, 2018
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Abstract (i) Purpose. The fluid challenge (FC) is a well-established test of preload reserve. Only limited data exist in regard to the FC efficacy based on infusion […]- Citation
- J Clin Hypertens (Greenwich). 2018 Nov;20(11):1615-1623.
- Date
- October 13, 2018
- Link
- View Link
Abstract Endothelial dysfunction indicates target organ damage in hypertensive patients. The integrity of endothelial glycocalyx (EG) plays a vital role in vascular permeability, inflammation and elasticity, […]- Citation
- J Neurosurg Anesthesiol. 2018 Jul 13. doi: 10.1097/ANA.0000000000000528.
- Date
- July 13, 2018
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Abstract Background: Fluid loading and hyperosmolar solutions can modify the cortical brain microcirculation and the endothelial glycocalyx (EG). This study compared the short-term effects of liberal fluid […]- Citation
- J Neurosci Methods. 2018 Jun 1;303:114-125. doi: 10.1016/j.jneumeth.2018.03.009. Epub 2018 Mar 22.
- Date
- June 1, 2018
- Link
- View Link
Abstract Introduction: The cerebral microcirculation and its glycocalyx, a matrix coating the luminal endothelium, are key regulators of capillary permeability and cerebral blood flow. Microvascular abnormalities are […]- Citation
- Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H531-H539. doi: 10.1152/ajpheart.00104.2018. Epub 2018 May 11.
- Date
- May 11, 2018
- Link
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Abstract Age-related microvascular dysfunction is well characterized in rodents and humans, but little is known about the properties of the microvascular endothelial glycocalyx in advanced age. […]- Citation
- J Clin Hypertens (Greenwich). 2018 Apr;20(4):672-679. doi: 10.1111/jch.13236. Epub 2018 Mar 2.
- Date
- March 2, 2018
- Link
- View Link
Abstract We investigated the association of endothelial glycocalyx damage with arterial stiffness, impairment of coronary microcirculatory function, and LV myocardial deformation in 320 untreated hypertensives and […]- Citation
- Microvasc Res. 2018 Jul;118:44-48. doi: 10.1016/j.mvr.2018.02.004. Epub 2018 Feb 17.
- Date
- February 17, 2018
- Link
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Abstract As of now the relationship between glycocalyx degradation and microcirculatory perfusion abnormalities in non-septic critical ill patients is unclear. In addition, conjunctival sidestream dark field-imaging […]- Citation
- Scand J Trauma Resusc Emerg Med. 2018 Feb 14;26(1):16. doi: 10.1186/s13049-018-0483-4.
- Date
- February 14, 2018
- Link
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Abstract Background: Deterioration of the endothelial glycocalyx (eGC), a protective carbohydrate-rich layer lining the luminal surface of the endothelium, plays a key role in vascular barrier dysfunction […]- Citation
- Microcirculation. 2018 May;25(4):e12454. doi: 10.1111/micc.12454.
- Date
- December 25, 2017
- Link
- View Link
Abstract Objective: PBR characterizes penetration of red blood cells inside glycocalyx and its thickness can have profound impact on microcirculation and other vascular parameters. The goal of […]- Citation
- Eur J Clin Invest. 2018 Feb;48(2). doi: 10.1111/eci.12869. Epub 2017 Dec 14.
- Date
- December 14, 2017
- Link
- View Link
Abstract Background and objective: Microcirculatory changes contribute to clinical symptoms and disease progression in chronic heart failure (CHF). A depression of coronary flow reserve is associated with […]- Citation
- Clin Hemorheol Microcirc. 2017;67(3-4):499-503.
- Date
- December 9, 2017
- Link
- View Link
Abstract The endothelial glycocalyx (EG) lining the endoluminal surface of the capillaries has been proposed as a key component of the microcirculation and a major player […]- Citation
- Kidney Blood Press Res. 2017;42(5):905-918.
- Date
- November 16, 2017
- Link
- View Link
Abstract Background: Cardiovascular disease is a major contributor to the poor outcomes observed in hemodialysis. We investigated the relationship between hemodialysis intensity and vascular parameters in high-dose […]
Studies on Endocalyx Pro effectiveness are ongoing. For the complete list, please go to Microvascular.com/Endocalyx-Pro-Studies
The Crucial Consortium brings together 12 partners from multiple fields (clinicians, fundamental scientists, scientific SMEs, exploitation and dissemination SME, management SME, and a patient advocacy), representing 7 different countries.
The Crucial Consortium aims to address a difficult problem regarding how co-morbidities give rise both to mental disorders and non-mental disorders. In order to achieve this, they have assembled a consortium that has a balanced mix of skills on several levels.
It consists of fundamental scientists and clinicians. It consists of specialists in neuroscience (UM, Scannexus) and in cardiovascular science (UCL, UNAV, FIMA, GlycoCheck, KU Leuven, VIB).
The clinical scientists are strong leaders in the field of MRI (UCL, UM, UNAV, Scannexus), whereas the fundamental partners have strong skills in molecular biology and genetics that will allow them to develop new biomarkers and identify new pathways for pharmaceutical targeting (FIMA, KU Leuven, VIB). Beyond bridging fundamental research and clinical applications, the project also combines several state-of-the-art technical approaches to answer the research objective. This includes cell signalling, (single cell) RNA-Seq, metabolic assessments, microvesicle’s biomarker identification, GlycoCheck measurements, and advanced imaging (MRI, 2-photon and light sheet microscopy). Read more here.
The Crucial Consortium has announced that they are launching a new study titled “Evaluation of miCRovascular rarefaction in vascUlar Cognitive Impairment and heArt faiLure (CRUCIAL): Study protocol for an observational study.” The abstract can be viewed by clicking the name of the study.

Healthy Aging is a Euregional project within the Interreg Euregio Maas-Rhine program . The partners (BIOMED is the lead partner) within this consortium ( BIOMED , MUMC + , GIGA Liège , UKA , Curador , MyHealth , Imomec , GlycoCheck , Astel Medica and DNAmito) use their expertise and knowledge to the maximum to detect premature aging of the immune system and to slow down aging and related chronic conditions. This consortium wants to develop cross-border knowledge platforms within the EMR for sharing and disseminating knowledge. Most of the activities in this project have a very specific medical-scientific focus. The partners of this project aim to innovate and validate the knowledge collected in the context of these activities. The results of this project should lead to lower healthcare costs. This project is supported by the European Regional Development Fund of the European Union which, through cross-border projects, provides innovation, stimulates a healthy environment and the labor market. More information can be found here. INTERREG Program and financing partners include:
Clinical Papers
Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit – the GlycoNurse study
Kuempers 2018: good intra-observer and excellent intra-class reproducibility of PBR measurements in ICU and ER patients; increased PBR in ICU patients compared with ER patients. PBR correlates with Mean Arterial Pressure (MAP) and with CRP and SOFA scores.
Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion
Weissgerber 2019: reproducibility of PBR measurements in pre-eclampsia patients increases when taking average of 2 or 3 measurements.
Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis
Kuempers 2019: PBR in patients correlates with plasma Syndecan-1 levels and with Atomic Force Microscope measurements of glycocalyx dimension on cultured endothelial cells exposed to patients' plasma.
Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall
Gorshkov 2018: Increase of PBR is associated with ischemic heart disease.
Experimental Papers
Rapid Insulin-Mediated Increase in Microvascular Glycocalyx Accessibility in Skeletal Muscle May Contribute to Insulin-Mediated Glucose Disposal in Rats
Eskens 2013:Insulin increases PBR, and hyaluronidase treatment of the glycocalyx abolishes the insulin effect
Early impairment of skeletal muscle endothelial glycocalyx barrier properties in diet-induced obesity in mice
Eskens 2014: PBR is increased in response to a High Fat Diet (figure 2D) and PBR correlates with increased duration and level of plasma glucose (area under the curve of glucose) after Glucose Tolerance Test.
Perturbed mechanotransduction by endothelial surface glycocalyx modification greatly impairs the arteriogenic process
Potter 2015: Inhibition of endothelial hyaluronan production increases PBR, which is associated with diminished glycocalyx dimension as measured with the Dextran 150kDa exclusion zone (figure 1).
Advanced age results in a diminished endothelial glycocalyx
Machin 2018: PBR increase in old mice is associated with decreased glycocalyx dimension, and increased PBR is associated with decreased glycocalyx dimension.